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Paper instructions:
I wrote a full outline about Sirtuins in general, however i would like you to edit it to be more specific, i want the outline to be about the role of sirtuins in the formation of skin cancer. The structure of the outline is good, so there is no need to change that. Take a look at the instructions file that i attached for details about how to edit the outline. The first page will show you what i would like you to make and the last page is a full outline example to show you what the final result should look like. Please, choose a specific research question and research topic, also write a thesis statement that is specific to the topic i chose. You can use the citations that i provided you with or find new primary citations, just make sure they are from primary sources. Also, make sure to cite them both in-text (see the example on the last page of the instructions attachment) and on the reference page. If you have any questions, please ask me and thank you.
ANSWER TO THE QUESTION
The Role of Enzymes Sirtuins in Cancer Development and Mitigation
- Introduction
- Research question/Focus: How are Sirtuins involved in tumor cells? Do Sirtuins cause cancer? Do Sirtuins suppress cancerous cells? (Jeong & Haigis, 2015)
- What are Sirtuins?
- What is the mechanism of Sirtuins? (German & Haigis, 2015)
- What is the link between Sirtuins and the formation of tumor cells?
- Research Topic
The bifunctional role of Sirtuins in cancer cells
- Overview of general/broad areas of interest
- Regulation of enzymatic activities in cancer cells (Martinez-Pastor & Mostoslavsky, 2012)
- Growth and development of cancer cells (Corbi, 2012)
- Promotion and suppression of cancer (Cha & Kim, 2013)
- Specific definition
- Cancer – tumor resulting from abnormal cell growth in the body
- Sirtuins – group of enzymes in the cells that regulate their biological pathways, including responses to stressors.
- Working thesis
The understanding of the twofold role of enzymes known as Sirtuins in the formation and suppression of cancer cells is imperative for the comprehension and postulation of new ways of employing them in the treatment of cancer.
- Body
- Organization strategy used
Experimental strategy was used where the mechanisms of Sirtuins in the formation of cancer cells were investigated in the laboratory
- Theme
Role of Sirtuins in cancer cell formation
- Topic sentence
Cells have a dual response to the mechanism of Sirtuins, and they can be used to control the growth of tumor cells Hirschey, (2011) and Lalla & Donmez, (2013).
- Transition to next theme
Sirtuins control the response of cancer cells to stressing conditions such as irradiations that kill the cells or alter their DNA configurations, metabolic alterations, and hyper-oxidative conditions Aioi, (2017)
- Theme 2
Sirtuins in skin cancer
- Topic sentence
Skin cancer develops based on the interpretation of the instructions of Sirtuins to the skin cells.
- Topic sentence
The skin cells accept the instructions from Sirtuins to use the foreign materials in the cells to develop cancer or simply mutate into cancer cells.
- Implication
- Review of holes in argument (limitations)
- The contribution of other enzymes in cancer cell activities is not addressed
- The research does not explore the possible negative side effects of Sirtuins to the normal cells in the body.
- Suggestion for future research
- Further research should be done focusing on the contribution of types of enzymes to the cancer cell activities
- Review/ summary main points
- Sirtuins are able to instruct the cells to die in unbearable conditions
- The complex role of Sirtuins in altering the cell responses can be useful for combating the formation of a tumor
- The complexity of the role of Sirtuins is due to its presentation of diverse enzymatic activities
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