DESCRIBE THE POST TRANSLATIONAL SYNTHESIS, STRUCTURE AND FUNCTION OF KERATIN. Describe the structure of the basement membrane zone (a diagram is acceptable),
include the main structural components and their attachments.
1. Answer both parts of this question:
a) Describe the post translational synthesis, structure and function of keratin.
(20 marks)
b) Describe the assembly of the cornified cell envelope, its structure and function.
(10 marks)
2. Answer all parts of this question:
a) Describe the structure of the basement membrane zone (a diagram is acceptable),
include the main structural components and their attachments. (10 marks)
b) Briefly describe the structure and function of focal contacts. (2 marks)
c) Briefly describe how the basement membrane zone is involved in wound healing
and name two (2) other functions of the basement membrane zone. (4 marks)
d) Name a genetic disease affecting the basement membrane zone in cattle and
name the structural component affected. (2 marks)
e) Name an auto-immune disease affecting the basement membrane zone in cats
and name the structural component affected. (2 marks)
f) Describe the pathomechanism of vesicle formation in canine epidermolysis
bullosa acquisita and contrast this mechanism with epidermolysis bullosa
simplex in dogs and other species. Include in your answer the ultrastructural
component affected in each species. (10 marks)
Section C continued over page
Veterinary Dermatology Paper 1 Page 9 of 9
3. Microbiome
Answer both parts of this question:
a) Describe and discuss the cutaneous bacterial microbiome that has been identified
on the dog and cat using culture dependent and independent techniques. Your
answer should include how the cutaneous microbiome varies in normal and
atopic individuals. (25 marks)
b) Briefly compare and contrast this animal cutaneous microbiome to the human
equivalent. (5 marks)
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