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1. Combination radiation therapy and cytotoxic chemotherapy provides better local control and
therapeutic ratio than radiation therapy alone for a number of malignancies. Discuss the
biological mechanisms of interaction of the two modalities to provide better local control.
Clinical Radiobiology – Previous Examination Papers
2. a. What factors determine local tumour control after a course of ionising radiation?
b. With the help of diagrams or graphs, describe dose-response relationships in tumours
and normal tissues.
3. Cell loss is an important kinetic factor which contributes to the dynamic state of tumour
growth.
a. Describe the mechanisms by which cell loss occurs.
b. How is cell loss measured in normal and neoplastic tissues?
c. What is the relevance of cell loss in tumour growth pre-irradiation and post-irradiation?
4. How do early and late radiation reactions differ with respect to latency, fractionation sensitivity
and overall treatment time?
a. Give an example of a defined scoring system for either early or late reactions.
b. What factors might contribute to severe acute or late radiation reactions seen in the
clinic?
5. In radiobiological terms, write short notes on THREE of the following:
a. The polymerase chain reaction
b. The radiobiological basis of radiation therapy in the management of benign neoplasms
and non-neoplastic diseases.
c. Radiation effects on the ovary
d. Shrinking field technique
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