The following parameters have been estimated for each of 3 different chemotherapy drugs under consideration for use in chemotherapy wafers (like Gliadel). Based on these values, discuss which compound will achieve the greatest penetration in tissue and which might be expected to have the greatest therapeutic effect.
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BCNU
4-HC
Methotrexate
Molecular weight
214
293
454
Log Koil/water
1.53
0.6
-1.85
k (s-1)
0.02
0.02
0.0003
D (10-7 cm2/s)
14
14
5
EC50 in cell culture
25
10
0.04
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