DISCUSS THE RELATIVE RADIOBIOLOGICAL ADVANTAGES AND DISADVANTAGES OF EACH STRATEGY.In the treatment of soft tissue sarcoma, external beam radiation therapy (EBRT) and brachytherapy implants are used in both preoperative and postoperative settings.
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Discuss the relative radiobiological advantages and disadvantages of each strategy In the treatment of soft tissue sarcoma, external beam radiation therapy (EBRT) and brachytherapy implants are used in both preoperative and postoperative settings. Discuss the relative radiobiological advantages and disadvantages of each strategy. Is there an ideal length of time between pre- and post-operative EBRT and surgery? If so, what are the possible radiobiological rationales guiding the timing of the two therapies? 2. Long waiting times for radiotherapy and interruptions in treatment have potentially adverse effects on treatment outcomes. Discuss the radiobiology of the tumour types likely to be most and least affected by such delays and the likely size of the effects. What radiobiologicalbased strategies might be employed to minimise the effects of treatment delays and interruptions? 3. (a) Describe the cellular and molecular defects in patients with Ataxia-Telangiectasia (A-T) that are responsible for their increased radiosensitivity and risk of malignancy. (b) Suppose you just cloned the A-T gene, ATM. Draw a table of the molecular assays you might consider using to characterise the gene, what the assay is capable of showing (or reason for the assay) and some findings you might see in A-T cells. 4. List the sources of ionising radiations to which human beings are and have been exposed. Draw a simple graph of the time course for the development of leukaemias and solid tumours in Hiroshima survivors. Discuss the radiobiologic basis of radiation carcinogenesis. 5. In radiobiological terms, write short notes on the following: a. The bystander effect b. Tumour clonogens c. The Ras gene d. Ionising radiation effects on the thyroid gland
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